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Abstract:
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Obesity is a condition where body weight exceeds normal limits which can
potentially lead to Diabetes Mellitus. The medicine to overcome this is a healty
diet using functional food that contain lots of fiber, one of which is Gracillaria Sp
seaweed formula Gracillaria Sp and Coffee on weight loss in mice, to find out
which functional food formula between Gracillaria Sp and Coffee had more
effect on weight loss in mice. This research was carried out using a quantitative
method True Experiment Pretest-posttest Control Group Design using a
completely randomized design (CRD)for 22 days. The sample consisted of 25
mice which where divided into 5 treatment groups, namely negative control (K-),
positive control (K+) given orlistat ,treatment 1 (P1) was given the formula
Gracillaria Sp 32 ml/day, treatment 2 was given the coffee formula 1,08ml/40 gr
bb/day, treatment 3 (P3) was given a mixture of Gracillaria Sp 32 ml/day +
coffee 1,08ml/40 gr bb/day. High fat diet for mice in the form of20 gr corn was
given once a day at 10 am during the fattening period and standard diet for mice
was 5 gr corn given during the treatment. The parameter measured was the weight
of the mice every three days during the treatment. The result of the one way
ANOVA test showed that the best formula with the most effect was P3
Gracillaria Sp 32ml/day+ Coffee 1,08 ml/40 gr bb/day could reduce the weight of
obese mice from 31,41 gr to 20,83 gr with p value < 0,05, almost equivalent to the
comparison orlistat (K+) from a weight of 32,12 gr to 21,46 gr. The result of the
ANOVA test on the consumption of mice p>0,05, with a significance
valuep=0,01, showed a significant difference to the consumption of mice. The
presence of fiber, flavonoids, and chlorogenicacid are thought to reduce the
breakdown of glucose, and play a role in inhibiting the activity of the lipase
enzyme that hydrolyzes fat that causes obesity. |